pI: 4.5489 |
Length (AA): 228 |
MW (Da): 25504 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 137 | 5vo5 (A) | 46 | 190 | 32.00 | 0 | 0.98 | 1.00232 | -0.54 |
11 | 227 | 5cwm (A) | 4 | 222 | 13.00 | 0.47 | 0.15 | 1.13685 | -0.66 |
24 | 100 | 4abm (A) | 22 | 97 | 33.00 | 0 | 0.73 | 0.841319 | -1.41 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Bloodstream Form. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127666)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G19830 | vacuolar protein sorting-associated protein 32-1 |
Arabidopsis thaliana | AT4G29160 | vacuolar protein sorting-associated protein 32-2 |
Babesia bovis | BBOV_III003020 | conserved hypothetical protein |
Brugia malayi | Bm1_42425 | Protein c20orf178 homolog |
Candida albicans | CaO19.13461 | involved in glucose derepression |
Candida albicans | CaO19.6040 | involved in glucose derepression |
Caenorhabditis elegans | CELE_C37C3.3 | Protein VPS-32.2 |
Caenorhabditis elegans | CELE_C56C10.3 | Protein VPS-32.1 |
Cryptosporidium hominis | Chro.50474 | hypothetical protein |
Cryptosporidium parvum | cgd5_3790 | SNF7 ortholog |
Dictyostelium discoideum | DDB_G0275573 | SNF7 family protein |
Drosophila melanogaster | Dmel_CG8055 | shrub |
Echinococcus granulosus | EgrG_001133200 | charged multivesicular body protein 4b |
Entamoeba histolytica | EHI_169820 | SNF7 family protein |
Echinococcus multilocularis | EmuJ_001133200 | charged multivesicular body protein 4b |
Homo sapiens | ENSG00000101421 | charged multivesicular body protein 4B |
Homo sapiens | ENSG00000254505 | charged multivesicular body protein 4A |
Leishmania braziliensis | LbrM.35.4080 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_364040.1 | Snf7, putative |
Leishmania infantum | LinJ.36.4040 | hypothetical protein, conserved |
Leishmania major | LmjF.36.3850 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.36.3850 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_00407 | charged multivesicular body protein 4b |
Mus musculus | ENSMUSG00000038467 | charged multivesicular body protein 4B |
Neospora caninum | NCLIV_064280 | hypothetical protein |
Oryza sativa | 4346566 | Os09g0267600 |
Oryza sativa | 4351360 | Os12g0121400 |
Oryza sativa | 4341494 | Os06g0608500 |
Onchocerca volvulus | OVOC10050 |
|
Plasmodium berghei | PBANKA_1456800 | vacuolar-sorting protein SNF7, putative |
Plasmodium falciparum | PF3D7_1243500 | vacuolar-sorting protein SNF7, putative |
Plasmodium knowlesi | PKNH_1462800 | vacuolar-sorting protein SNF7, putative |
Plasmodium vivax | PVX_101075 | vacuolar-sorting protein SNF7, putative |
Plasmodium yoelii | PY01275 | nuclear protein snf7 |
Saccharomyces cerevisiae | YLR025W | ESCRT-III subunit protein SNF7 |
Schistosoma japonicum | Sjp_0305290 | Charged multivesicular body protein 4b, putative |
Schistosoma mansoni | Smp_045710.2 | snf7-related |
Schistosoma mansoni | Smp_045710.1 | snf7-related |
Schmidtea mediterranea | mk4.005056.00 | GH13992p |
Schmidtea mediterranea | mk4.003714.00 | GH13992p |
Trypanosoma brucei gambiense | Tbg972.11.10810 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.9630 | Snf7, putative |
Trypanosoma congolense | TcIL3000_0_20540 | Snf7, putative |
Trypanosoma congolense | TcIL3000.11.10130 | Snf7, putative |
Trypanosoma cruzi | TcCLB.511229.100 | Snf7, putative |
Trypanosoma cruzi | TcCLB.511589.250 | Snf7, putative |
Theileria parva | TP04_0143 | hypothetical protein |
Trichomonas vaginalis | TVAG_459530 | vacuolar sorting protein SNF7, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.1390 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.1390 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.1390 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.1390 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C37C3.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C37C3.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C37C3.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C37C3.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C56C10.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C56C10.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C56C10.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C56C10.3 | Caenorhabditis elegans | slow growth | wormbase |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.